RAD-140 Testolone SARM Review | Where To Buy | Benefits 2019

SARMS Vendor

Let’s take a look at our review of RAD-140 or Testolone, an experimental compound that is currently being researched for use in the treatment of muscle degeneration and cancer. It is classified as a SARM and it modulates some of the body’s metabolic processes in select tissue types.

Disclaimer: We are not recommending taking this product, yet simply reviewing the product based on our research. RAD-140 (Testolone) is sold for research purposes only & is not approved for human use or consumption! Please do your own research before making any decisions related to RAD-140 (Testolone).

Where To Buy RAD-140 Testolone

ProvenPeptides is a reputable provider of SARMs & does have RAD-140 (Testolone) available for purchase. 

Current medical status

Currently, RAD-140 is not being prescribed to treat any medical condition as it has not yet been fully cleared for regular use in humans. However, current trends show that professional bodybuilders and athletes are already using this research compound to enhance their performance and physical capabilities.

SARMS or selective androgen receptor modulators are compounds that bind to the androgen receptor, which is normally activated (under more natural conditions) by the male hormone testosterone. Testosterone is naturally produced by the body, but its effects can be approximated by both steroids and SARMs.

To clarify, SARMs can create similar secondary effects that are normally associated with steroids, but these compounds are not steroids. It just so happens that they can bind to the specific receptors in tissues to express certain genes, which consequently produces metabolic changes in the body.

Testolone and breast cancer

Current studies on this experimental compound are focused in determining if RAD-140 can help individuals suffering from muscle deterioration and breast cancer.

Breast cancer is one of the more common types of cancer in women, and if left untreated, can easily metastasize or spread to other organs, such as the liver, lungs, bones, etc.

Compounds that have androgenic effects such as testosterone and androastenedione are used in hormone replacement therapies in situations where the body is not producing enough of the natural hormone to sustain normal metabolic processes in the body.

Testosterone and physical development

The male hormone testosterone is responsible not just for the secondary sexual characteristics of males, but also for the normal development of bones, teeth, skin, etc.

Physical strength, muscular endurance and other aspects of the physiology that are associated with physical performance are also associated with the male hormone. Having too much or too little of the natural male hormone in the body can lead to disease.

When the body doesn’t have enough of the male hormone, it undergoes marked changes, like loss of bone density, brittle bones, loss or reduction of lean muscle mass, reduction of muscular endurance, etc.

Side effects of testosterone

However, let it be known that hormone replacement therapy with androgenic compounds does have its downsides or side effects.

Among the known side effects in are liver damage, testicular masses, infertility (in both men and women), prostate cancer and “roid rage” or psychotic breaks from reality, as a result of long-term use of steroids.

Due to the serious risks and side effects associated with androgenic substances, researchers have taken upon themselves to find out if SARMs can help reduce the risk factors associated with hormone replacement therapy by introducing newer, more experimental compounds such as RAD-140 or Testolone.

In recent years, the extensive studies done on Testolone and other affiliated compounds have yielded mostly positive results, mainly because SARMs only activate secondary, hormone-associated effects in select tissues.

For instance, Testolone is associated with muscles and bones, it won’t cause the same amplified metabolic effect on the liver, stomach or intestines. The same cannot be said when you use more conventional compounds such as as synthetic testosterone, though these compounds have been in vogue in certain fields for decades now.

RAD-140 has a unique chemical structure that does two things: it does not mimic testosterone, which means it won’t cause secondary effects in other organs and second, it is able to maintain the integrity of its chemical structure as it is metabolized, which means it won’t be transformed to any other compound once it passes through the kidneys or liver.

In animal studies, RAD-140 has shown low toxicity in the liver (i.e. it does not cause any undue increases in the production of enzymes in this organ) and it also does not stimulate any tissue growth in the testes or in other sex organs (like the ovaries in women).

This is good news as any damage caused by overstimulation due to androgenic substances can cause permanent damage or chronic disease.

Potential Medical Benefits

As for the potential uses in RAD-140 once it has been approved for regular human use, researchers have hinted on the following medical benefits:

Lean muscle development

Severe, chronic diseases such as AIDS and many types of advanced cancers cause massive lean muscle tissue loss and fat loss. Uncontrollable weight loss is exceedingly common in patients suffering from these conditions.

RAD-140 has shown potential in reversing muscle and bone degeneration. If taken, RAD-140 stimulates the growth of both types of tissues while omitting other organs, making it safer than synthetic male hormones.

Selectivity is its primary strength as a healing compound; current research shows that it does not stimulate overgrowth of the prostate gland, which can then result either in prostate-related blockages, tumor growth or even prostate cancer.

Breast cancer

AR/ER+ breast cancer has also been proven responsive to Testolone. While Testolone’s secondary effects is primarily associated with bone and muscle growth, it has also been shown to suppress or combat the growth and spread of cancer cells.

How is Testolone able to do this? When Testolone is absorbed by the body, it selectively prohibits the action of estrogen in select tissues. Estrogen has been linked to accelerated tumor growth. Breast cancer can rapidly metastasize through the creation of multiple tumors throughout the breast tissue.

Better brain and nerve health

Another interesting benefit of RAD-140 is it may support individuals who are suffering from chronic, degenerative neurological conditions such as Alzheimer’s disease.

It’s able to accomplish this by protecting the nervous system from amyloid beta proteins, which are considered the main culprits in causing irreparable damage to the brain tissue.

While the rese results are derived from animal studies, RAD-140 shows much promise as mammalian tests are often indicative to a certain percentage of success once testing is done on humans in Phase 1 medical studies.

Again, RAD-140 is not converted to estrogen and other hormones, even as it is being metabolized by the body. It retains its structure and continues performing its primary actions throughout its ‘life’ inside the body.

This is one of the SARMs in our series of reviews. 

LGD-4033 Ligandrol SARM Review | Where To Buy | Benefits 2019

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A look at our review of the SARM Ligandrol LGD-4033 is a non-steroidal SARM, which has shown to produce secondary ergogenic effects in the human body.

Ligandrol produces steroid-like effects, but it is not a steroid and therefore, cannot be considered a replacement for the synthetic male hormone, testosterone, and other steroidal substances used for hormone-replacement and other associated medical therapies.

Disclaimer: We are not recommending taking this product, yet simply reviewing the product based on our research. LGD-4033 Ligandrol is sold for research purposes only & is not approved for human use or consumption! Please do your own research before making any decisions related to LGD-4033 Ligandrol.

Where To Buy LGD-4033 Ligandrol

ProvenPeptides is a reputable provider of SARMs & does have LGD-4033 Ligandrol available for purchase. 

Classification and mode of action

Ligandrol is classified as a ligand androgen receptor, which makes it influence certain metabolic processes in the body. It is also tissue-specific, meaning it only serves to active gene expressions in select tissue types.

Ligandrol has been shown to be promising in four main areas of tissue regeneration: muscle wasting, age-related muscle reduction (due to inactivity, poor nutrition, poor nutrient uptake or general slowdown in muscle tissue production), bone regeneration and protection (as a result of osteoporosis or the degeneration of bones), and finally, cancer.

Ligandrol was first developed by Viking Therapeutics, with the initial goal of coming up with a therapeutic compound that provided the healing properties of the more well-known male hormone minus the established side effects, such as testicular masses, testicular shrinkage, liver cysts, abnormal breast growth in males, etc. Ligandrol is administered orally.

To date, Ligandrol is considered the most potent of all SARMs available for research, and remains a promising therapy for tissue degeneration.

Track record

Let’s talk about why SARMs like Ligandrol have a better track record than the synthetic male hormone, testosterone. SARMs function in almost the same way as testosterone, but the key difference is that SARMs like Ligandrol are almost always tissue-specific.

This simply means that once ingested, Ligandron will not be affecting tissues of other organs like the skin, testes, etc.

These areas are often ‘hit’ by testosterone and other steroids, increasing the likelihood of serious health conditions down the road.

From a broader perspective, SARMs counterbalance the risks associated with hormone therapies to provide increased benefits to users or patients while whittling down known side effects.

Ligandrol has been subjected to a Phase 1 medical trial to better understand its mechanisms of action and benefits to the human body. Existing literature points at mostly positive effects when used alone or in conjunction with other SARMs.

Due to its exclusive effect on the muscles and bones, many scientific researchers have alluded to its potential as an aid in athletics, specifically in muscle gain and better treatment of sports-related injuries.

Benefits/Effects of Ligandrol

In contrast with prohormones and the synthetic male hormone, patients will not experience any massive increases in weight.

And while it’s normal for a patient undergoing male hormone therapy to experience weight gains of up to 20 pounds, a Ligandrol user will only experience an average weight gain of less than or equal to two pounds for every week of regular use.

In professional bodybuilding, a week may refer to what is called a ‘cycle,’ or the process of reducing body fat while working intensely on specific muscle groups to increase the volume of musculature. It was observed that patients on a 21-day cycle with Ligandrol experienced the highest observable changes in the volume of lean muscle tissue.

Would it be possible to gain more than the average poundage per week? Yes, but only if the patient put in the necessary training and diet to achieve this end.

Otherwise, the average weight gain will be maintained. On the upside, all weight gains are attributed to lean muscle growth; water weight or bloating are not typical results of using Ligandrol for any specific therapies.

Patients using this drug are also advised to maintain a high calorie and high protein diet to sustain the benefits of using this SARM.

LGD-4033 Ligandrol Increased Muscle Strength

Parallel to lean muscle development is a palpable increase in muscle strength. It is believed that the enhancement of muscle strength precedes lean muscle development, as increased muscle strength leads to better chances of developing more muscle volume.

This emphasizes the need for the patient or user to train the muscles, in order to build the desired mass.

– It also appears that Ligandrol may be sufficient as complementary therapy for individuals who wish to shed fat tissue through exercise. Normally the body can shed fat when it needs energy; SARMs like Ligandrol only serve to enhance this natural function of the body.

When the body switches from sugar/glucose to fat during physical activity, the body is deemed catabolic. This catabolic reaction is much sought after in professional bodybuilding and sports, as shedding fat is important for maintaining weight or a muscular physique.

On a more practical level, catabolic energy expenditure obviously helps people maintain their weight, as excess energy is stored as adipose tissue.

The keyword here is optimize. Ligandrol is not magical therapy. It only serves to optimize what are already natural processes in the body.

But since metabolism is largely tricky to control, it’s easy to understand why people would be interested in Ligandrol as a possible alternative in hormone therapy, should their physicians require them to undergo such a kind of treatment.

Bone density and strength

Now, in addition to addressing issues with lean muscle tissue development, the Phase 1 study performed on this drug has shown that it also activates periosteal bone development. PBD is vital for maintenance of strong bones and pliable joints.

Again, from a more practical point of view, better joint and bone health translates to enhanced physical performance, no matter what a person is currently engaged in, fitness-wise. What’s interesting here is that bone development is also dependent on muscular strength and health.

Why? Because the more a patient exercises, the more the bones are activated to develop strong tissues, to withstand the current influx of physical activities.

So the body really does to toughen itself up. SARMs like Ligandrol may boost the regenerative functions of selective tissues, to ensure that a person’s physiology is well-equipped to handle the current levels of physical stress.

Yes, exercise and all other forms of physical training are considered stress. But unlike emotional stress, physical stress in the form of exercise might be good for the body.

This is one of the SARMs in our series of reviews.

GW-501516 Cardarine SARM Review | Where To Buy | Benefits 2019

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Let’s look at our review of Cardarine or GW-501516, a hormone receptor that has been associated with lean muscle growth and increases in cardiovascular endurance.

Disclaimer: We are not recommending taking this product, yet simply reviewing the product based on our research. Cardarine is sold for research purposes only & is not approved for human use or consumption! Please do your own research before making any decisions related to Cardarine.

Where To Buy GW-501516 Cardarine SARM

ProvenPeptides is a reputable provider of SARMs & does have Cardarine available for purchase. 

How Does GW-501516 Cardarine Work

The primary action of cardarine is it seeks, binds and consequently activates the PPAR or the peroxisome proliferator activator receptor. It is a transcription factor, and is considered a part of the nuclear hormone receptor superfamily.

It is ‘expressed’ or is part of the normal gene expressions of varied tissues found in the human body. And like other hormone receptors, it allows the expressions of specific metabolic activities in the body in a very systematic and consistent manner.

Cardarine and adipose tissue expression

What is of primary interest to researchers is the fact that PPAR delta (which has high affinity to cardarine) is expressed mainly in adipose tissue or fat tissues.

Fat tissues are everywhere in the body: this layer is found directly beneath the skin and is highly concentrated around the breasts (in women), abdominal region, thighs, etc.

Adipose tissue is a loose type of tissue and its presence throughout the body means any increase in activity of PPAR delta will influence various systems (e.g. cardiovascular, just to name one). GW-501516 was first manufactured by the pharmaceutical giant GlaxoSmithKline, in cooperation with another notable industry player Ligand Pharmaceuticals way back 1992.

Clinical examinations have shown that cardarine triggers the activation of the PGC-1a enzyme. This enzyme is responsible for the articulation of specific genes that affect how energy is expended or utilized in the body.

It is no small wonder that as far back as the early nineties, this SARM has been of immense interest to proponents of physical fitness, as the natural regulation of energy expenditure at the cellular level is considered ‘the final frontier’ in mastering how human metabolism works.

Cardarine has gained some exposure in recent years due to its secondary effects on the body, which benefit individuals who regularly strain their physiques.

This includes athletes, bodybuilders, and other people who regularly push their physiologies to the limit in terms of performance.

This compound has gained a reputation for increasing the athletic threshold of healthy adults, allowing them to increase their performance even when they approach their maximum levels of strain.

Cardarine and other SARMs

How does Cardarine compare to similar substances such as Trenbolone? While it’s true that there are plenty of other substances out there that produce similar anabolic effects, it appears that Cardarine is able to decrease troublesome side effects, such as respiratory issues during high intensity, interval training and other similar situations.

We can safely assume that high intensity physical activities of the non-athletic kind will also receive the same advantage, if Cardarine is in the picture.

Cardarine doesn’t just provide an extra boost of strength to athletes; it also enhances endurance. How does endurance differ from strength? There’s mighty big confusion with these two terms as they both describe the capacity of the muscles and bones to withstand stress.

Technically, endurance is the ability of something to overcome stress or pressure before giving way. In the context of physical endurance, the body is very finite when it comes to what it can do, how much it can withstand and for how long.

Physically challenging activities, like sustained efforts in the gym can stretch a person’s endurance. Those competing in professional sports would obviously work toward expanding their endurance levels, so that normal muscular exhaustion would become a thing of the past.

Overcoming endurance problems often requires plenty of training, a diet sufficient in protein and if needed, hormone therapies as prescribed by a professional healthcare provider.

See our review of MK-2866 Ostarine.

Cardarine and professional athletics

Presently, the WADA (World Anti-Doping Agency) prohibits the use of Cardarine in professional sports. To clarify, it is technically not a SARM, but it does produce anabolic effects and it will most likely enhance the physical capability and endurance of users, which turns it into a questionable substance if an athlete is competing professionally.

Why did WADA decide to block this substance? If we look at what it does in the body from a broad perspective, it moderates a person’s metabolism and also activates the AMPK (or protein kinase). Therefore, it will naturally increase the threshold of physical endurance as long as it is taken.

Medical Benefits of Cardarine

Current medical literature provides us with an overview of the positive impact of GW-501516 to the body. The first benefit is it helps prevents plaques or atherosclerotic blockages from occurring. These blockages occur in the heart and its associated blood vessels.

GW-501516 appears to have anti-inflammatory properties as well as anti-plaque capabilities. This improves overall heart health and circulation, especially during periods of extreme physical stress.

The second benefit concerns the brain. If Cardarine can reduce blockages in the heart, it has also been shown to be effective cutting down plaques in the brain.

What does this mean? Well, the brain is one of the organs in the body that just has to have a rich supply of oxygen all the time. When the blood supply cuts out due to a blockage (we call this a stroke), the brain can take severe damage.

Cardarine not only helps in preventing blockages in the blood vessels in the brain, it also protects those blood vessels from oxidative stress due to free radicals. Free radicals are harmful byproducts of cellular metabolism. While the body has sa natural means of getting rid of free radicals, a person’s environment and lifestyle can increase the production of free radicals to the point that cells begin to age and die at a more rapid pace.

Animal tests have also confirmed that the tiny, packed blood vessels in the kidneys can also benefit from this ergogenic substance.

Cardarine may be able to protect the blood vessels in the kidneys by reducing the expression of the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2), which has been established as a key player in the genesis of nephropathy or kidney disease.

MCP-1/CCL2 has also been linked to heart diseases and the hardening of blood vessels (plus subsequent build-up of plaque in arteries and veins).

MK-2866 Ostarine SARM Review | Where To Buy | Benefits 2019

SARMS Vendor

We’ll be doing a review of MK-2866 or Ostarine in this article. This supplement is a SARM designed to reduce muscle wastage, address muscle atrophy and reduction, and ward off cachexia and sarcopenia.

It is a selective androgen receptor module, and can be utilized during hormone therapy and/or instances that an individual has been deemed at risk because of low testosterone levels.

It has been noted that individuals who regularly take ostarine not only avoid muscle wastage but were also able to increase muscle mass over a period of time.

Disclaimer: We are not recommending taking this product, yet simply reviewing the product based on our research. MK-2866 Ostarine is sold for research purposes only & is not approved for human use or consumption! Please do your own research before making any decisions related to MK-2866 Ostarine.

Where To Buy MK-2866 Ostarine

ProvenPeptides is a reputable provider of SARMs & does have MK-2866 Ostarine available for purchase. 

Benefits of Ostarine

Ostarine is often mistaken for an earlier compound called ‘S1’ in the market, but there should be no confusion – the ‘S1’ SARM is no longer under active development.

Ostarine has been proven relatively safe for regular consumption; users have reported consistent gains in muscle mass.

Though the gains are small, they are continuous if ostarine is included in any regular therapy or regimen, as guided by a qualified healthcare specialist. The build-up of muscle mass will become more noticeable over a long period of use.

A healthy adult engaged in regular physical fitness activities may gain up to 10 pounds of muscle mass with the help of this SARM, though a specialized diet may be required to sustain the muscle gains. As with all forms of muscle gains, continued resistance training and sufficient nutrition is required to maintain firm musculature.

Some of the general observable effects of Ostarine include the following: Consistent gains of lean muscle mass over a period of time, increased muscular strength during periods of resistance and strain, increased physical endurance, improved joint regeneration after strain and injury, and anabolic effects even in low dosages.

Although Ostarine has a notable anabolic impact on the body, it is not identical to anabolic steroids. Anabolic steroids are a distinct class of substances and are used to treat low testosterone levels, among other health conditions.

How Does MK-2866 Ostarine Work

Ostarine binds primarily with the androgen receptor, and causes changes in both bone and muscle activity. The effect is selective and controlled, which determines the safety level of Ostarine in any clinical setting.

Regular intake of the compound induces an increase of protein synthesis at target sites, causing small gains over time. Ostarine helps increase muscle mass and prevents muscle wasting, minus the secondary side effects associated with anabolic steroids.

Some of the more common side effects of anabolic steroids include liver cysts, unusual breast growth in males and prostate/testicular issues. These side effects are well-documented clinically and a GP will be able to tell you about the side effects of anabolic steroids during your consultation.

Ostarine is notable not just for muscle growth during intense physical activity, but also muscle gains after surgery and chronic conditions such as cancer.

It appears that lack of physical activity is not an obstacle to the primary impact of ostarine to the body, which means cancer patients may also benefit from it as genera muscular wastage is exceedingly common in patients suffering from advanced cancer.

MK-2866 Ostarine Human Clinical Trials

To date, one manufacturer, GTx, has subjected the compound to no less than three effectiveness trials involving more than 500 respondents.

A separate Phase II-B Medical Trial that involved a total of 159 patients has also been undertaken to examine the direct impact of ostarine on the lean muscle volume of healthy adults.

In the Phase-II B Medical Trial, ostarine was pitted against a placebo for a period of four months. Progressive muscular strength was noted in the majority of the 159 respondents, confirming yet another facet of ostarine in improving musculoskeletal robustness.

Ostarine and bone mineral density

How does ostarine help the bones?

Why is this even important? For athletes and other individuals who rely on physical strength and endurance, bone strength and recuperation is of utmost importance. The same can be said for aging individuals and people afflicted with brittle or weak bones.

As was previously mentioned in this article, ostarine has a secondary anabolic effect on the bones as well. This effect impacts bone strength and regeneration, which means ostarine may soon be used as a complementary therapy for individuals with osteoporosis and other similar chronic, degenerative bone conditions.

This compound may also be useful for individuals suffering from lower bone density as a result of previous therapies. Some therapies reduce bone density as a side effect.

Ostarine may be prescribed as a parallel treatment to swiftly counteract the harmful effects of bone-reducing drugs. Ostarine’s anabolic activity also benefits cartilaginous parts of the body, including major and minor joints. Individuals suffering from athletic injuries may recover more quickly with the help of this compound.

MK-2866 Ostarine Dosing

Individuals who require the aid of non-steroidal, anabolic aid from ostarine have shown laudable results even with mild or low dosing. The average dosing can be as low as 25 milligrams or double the amount, taken every 24-36 hours, depending on the recommendation of the GP/specialist.

As of this writing, there is no medical literature that indicates any increase in the effectiveness of ostarine beyond the 50 milligram mark, which means low dosing is the ideal.

As for the safety record of this drug over a longer time frame, current studies indicate safe use for up to six months, or 24 weeks. Ostarine is well-tolerated and no serious side effects have been noted in formal literature.

How has ostarine been used in athletic settings? Individuals engaged in regular strength training regimens have noted muscle gains of up to six pounds (lean muscle mass) after using ostarine for up to six weeks. Six weeks corresponds to a fraction of the period deemed safe for this compound.

Dosages above 25 milligrams are recommended for individuals weighing more than 200 lbs. The maximum dosing of 50 milligrams often never used, as daily intake of 36 milligrams appears to be sufficient for the purpose of protecting lean tissue from wear and tear, and increasing overall lean muscle mass/volume.

36 milligram dosing often requires intake for a period of eight weeks. The diet requirement is centered on proteins – the overall protein content of the individual’s diet should be no less than 30% in order for ostarine’s anabolic activity to achieve maximum impact.

See our review of GW-501516 Cardarine SARM

Notice! If any of this information has been reported inaccurately, please let us know so that we can edit or remove said parts.