GW-501516 Cardarine SARM Review | Where To Buy | Benefits 2019

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Let’s look at our review of Cardarine or GW-501516, a hormone receptor that has been associated with lean muscle growth and increases in cardiovascular endurance.

Disclaimer: We are not recommending taking this product, yet simply reviewing the product based on our research. Cardarine is sold for research purposes only & is not approved for human use or consumption! Please do your own research before making any decisions related to Cardarine.

Where To Buy GW-501516 Cardarine SARM

ProvenPeptides is a reputable provider of SARMs & does have Cardarine available for purchase. 

How Does GW-501516 Cardarine Work

The primary action of cardarine is it seeks, binds and consequently activates the PPAR or the peroxisome proliferator activator receptor. It is a transcription factor, and is considered a part of the nuclear hormone receptor superfamily.

It is ‘expressed’ or is part of the normal gene expressions of varied tissues found in the human body. And like other hormone receptors, it allows the expressions of specific metabolic activities in the body in a very systematic and consistent manner.

Cardarine and adipose tissue expression

What is of primary interest to researchers is the fact that PPAR delta (which has high affinity to cardarine) is expressed mainly in adipose tissue or fat tissues.

Fat tissues are everywhere in the body: this layer is found directly beneath the skin and is highly concentrated around the breasts (in women), abdominal region, thighs, etc.

Adipose tissue is a loose type of tissue and its presence throughout the body means any increase in activity of PPAR delta will influence various systems (e.g. cardiovascular, just to name one). GW-501516 was first manufactured by the pharmaceutical giant GlaxoSmithKline, in cooperation with another notable industry player Ligand Pharmaceuticals way back 1992.

Clinical examinations have shown that cardarine triggers the activation of the PGC-1a enzyme. This enzyme is responsible for the articulation of specific genes that affect how energy is expended or utilized in the body.

It is no small wonder that as far back as the early nineties, this SARM has been of immense interest to proponents of physical fitness, as the natural regulation of energy expenditure at the cellular level is considered ‘the final frontier’ in mastering how human metabolism works.

Cardarine has gained some exposure in recent years due to its secondary effects on the body, which benefit individuals who regularly strain their physiques.

This includes athletes, bodybuilders, and other people who regularly push their physiologies to the limit in terms of performance.

This compound has gained a reputation for increasing the athletic threshold of healthy adults, allowing them to increase their performance even when they approach their maximum levels of strain.

Cardarine and other SARMs

How does Cardarine compare to similar substances such as Trenbolone? While it’s true that there are plenty of other substances out there that produce similar anabolic effects, it appears that Cardarine is able to decrease troublesome side effects, such as respiratory issues during high intensity, interval training and other similar situations.

We can safely assume that high intensity physical activities of the non-athletic kind will also receive the same advantage, if Cardarine is in the picture.

Cardarine doesn’t just provide an extra boost of strength to athletes; it also enhances endurance. How does endurance differ from strength? There’s mighty big confusion with these two terms as they both describe the capacity of the muscles and bones to withstand stress.

Technically, endurance is the ability of something to overcome stress or pressure before giving way. In the context of physical endurance, the body is very finite when it comes to what it can do, how much it can withstand and for how long.

Physically challenging activities, like sustained efforts in the gym can stretch a person’s endurance. Those competing in professional sports would obviously work toward expanding their endurance levels, so that normal muscular exhaustion would become a thing of the past.

Overcoming endurance problems often requires plenty of training, a diet sufficient in protein and if needed, hormone therapies as prescribed by a professional healthcare provider.

See our review of MK-2866 Ostarine.

Cardarine and professional athletics

Presently, the WADA (World Anti-Doping Agency) prohibits the use of Cardarine in professional sports. To clarify, it is technically not a SARM, but it does produce anabolic effects and it will most likely enhance the physical capability and endurance of users, which turns it into a questionable substance if an athlete is competing professionally.

Why did WADA decide to block this substance? If we look at what it does in the body from a broad perspective, it moderates a person’s metabolism and also activates the AMPK (or protein kinase). Therefore, it will naturally increase the threshold of physical endurance as long as it is taken.

Medical Benefits of Cardarine

Current medical literature provides us with an overview of the positive impact of GW-501516 to the body. The first benefit is it helps prevents plaques or atherosclerotic blockages from occurring. These blockages occur in the heart and its associated blood vessels.

GW-501516 appears to have anti-inflammatory properties as well as anti-plaque capabilities. This improves overall heart health and circulation, especially during periods of extreme physical stress.

The second benefit concerns the brain. If Cardarine can reduce blockages in the heart, it has also been shown to be effective cutting down plaques in the brain.

What does this mean? Well, the brain is one of the organs in the body that just has to have a rich supply of oxygen all the time. When the blood supply cuts out due to a blockage (we call this a stroke), the brain can take severe damage.

Cardarine not only helps in preventing blockages in the blood vessels in the brain, it also protects those blood vessels from oxidative stress due to free radicals. Free radicals are harmful byproducts of cellular metabolism. While the body has sa natural means of getting rid of free radicals, a person’s environment and lifestyle can increase the production of free radicals to the point that cells begin to age and die at a more rapid pace.

Animal tests have also confirmed that the tiny, packed blood vessels in the kidneys can also benefit from this ergogenic substance.

Cardarine may be able to protect the blood vessels in the kidneys by reducing the expression of the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2), which has been established as a key player in the genesis of nephropathy or kidney disease.

MCP-1/CCL2 has also been linked to heart diseases and the hardening of blood vessels (plus subsequent build-up of plaque in arteries and veins).

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