In this post we’ll be doing a review of MK-677 or Nutrobal, a SARM used as a growth hormone secretagogue. Essentially, Nutrobal is administered in patients to stimulate the natural release of the growth hormone. The human growth hormone (HGH) is secreted by the pituitary gland.
Originally, Reverse Pharmacology formulated this experimental compound to help individuals who are suffering from degenerative conditions such as osteoporosis and muscle wastage.
Disclaimer: We are not recommending taking this product, yet simply reviewing the product based on our research. MK-677 Nutrobal is sold for research purposes only & is not approved for human use or consumption! Please do your own research before making any decisions related to MK-677 Nutrobal.
Where To Buy MK-677 Nutrobal
Nutrobal has is also being researched for its potential as therapy for type 2 diabetes, or adult-onset diabetes. Currently, two important findings are most prominent when researchers talk about MK-677: that this experimental compound increases lean muscle tissue and it also increases the production of IGF-1 serum concentration. IGF-1 is a natural growth factor in the body that helps boost bone and muscle growth.
As a SARM, Nutrobal essential mimics the function of testosterone and other substances used conventionally in hormone replacement therapies. By function and structure, MK-677 is comparable to Ipamorelin, and GHRP-6. Ipamoreline is also a growth hormone secretagogue and selective agonist of the GHS. It was derived from GHRP-1.
GHRP-6 or the growth hormone-releasing hexapeptide is a synthetic met-enkephalin analogue, and is administered primarily to stimulate the release of the human growth hormone (HGH). As can easily be seen, Nutrobla, GHRP-1 and GHRP-6 all perform similar functions – they stimulate the production and release of HGH, which is necessary for the normal growth and repair of various tissue types in the human body.
From the outset, substances like MK-677 are considered game-changing developments in the field of medicine because they are able to produce the same healing effects as the male hormone testosterone without bringing to the table serious side effects associated with hormone replacement therapy.
Patients who are suffering from muscle wastage due to advanced cancer, for instance, now have an option apart from testosterone if they wish to replicate the same effects on their body. Physicians will now also have the option of being able to replace the direct administration of the human growth hormone and other androgenic substances with more experimental compounds like MK-677.
In primary medical studies, Nutrobal has been shown to inhibit somatostatin in the body. Somatostatin or the growth hormone inhibiting hormone (GHIH) is a type of peptide hormone that modulates the endocrine system and counters the effects of the human growth hormone.
It primarily serves to inhibit the release and subsequent action of HGH in the body. In the context of medical intervention that is centered on building bone density and lean muscle mass, GHIH is an antagonizing factor in the equation. Nutrobal counters the negative impact of this naturally-occurring compound, allowing for the increased release, absorption and action of the human growth hormone from the pituitary gland.
Nutrobal works in four phases to antagonize the action of GHIH or somatostatin: first, it reduces the signaling of the hormone receptors responsible for the release of somatostatin. Second, it addresses somatostatin that has already been released in the system by slowing down its primary mechanism, which is the inhibition of the human growth hormone. In the third phase of its action, it turns its attention to the hormone signaling and reception of HGH.
It makes the signaling and subsequent release more efficient, thereby increasing the serum concentration of HGH in the body. And finally, after improving the signaling of the receptors necessary for the release of HGH, Nutrobal engages the pituitary gland to further improve the general production of the human growth hormone. This process is called hormone amplification and is very normal, too. In certain situations, the body performs the same amplification whenever tissue growth or development becomes necessary.
Due to a subsequent, rapid increase in HGH as a result of Nutrobal administration, the human body will naturally undergo the following changes:
– Soft-tissue injuries as well as joint/ligament injuries will resolve more rapidly, as ligaments and tendons will receive a developmental boost. Bones will also strengthen and the recovery time for bone injuries will shorten. Old injuries will also be addressed, as all sites that require healing and tissue regeneration will benefit from Nutrobal.
– Lean muscle mass will increase in volume, minus the usual bloating and water weight associated with mass gains. We have to emphasize here that lean muscle development is a complex phenomena and normally, the process is incredibly gradual and requires just the right number of factors to come to fruition. Research compounds like Nutrobal speed up the process of development, which means any patient being administered this compound can expect consistent results over a period of time, as oppose to just observing what would naturally occur, as dictated by a person’s body type and gene line-up.
– Nutrobal has also been shown to oxidize fat, which leads to better, faster metabolism. A patient with excess fat but low lean muscle mass will benefit from Nutrobal as the body will use the fat for energy (as opposed to lean muscle tissue) while protecting existing musculature from further degeneration.
Researchers have also observed substantial skin tightening upon administration. Why is this relevant? Patients who lose adipose or fat tissue often complain of loose skin after. Sagging skin is aesthetically problematic and in some cases, surgery becomes necessary to remove excess skin as a result of weight loss. Compounds like Nutrobal may be able reduce the need for skin surgery if its science advances to the point that its positive effects are greatly amplified for target tissue types in the body.
– Does MK-677 affect a person’s sleep cycle? Apparently, it does. Current users of this compound have reported deeper and more restful sleep after regular administration of the compound. Another interesting aspect of improved sleep is the heightening of vivid dreaming.
From the perspective of sleep science, increased dreaming may point to increased excitability of the brain during sleep, which paradoxically means that the person is experiencing less restful sleep, overall. However, from the point of view of a person who has not been able to experience long periods of deep sleep for a long time, MK-677 may not be so bad a choice for hormone replacement therapy.
There are other SARMS out there as well such as: