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Today’s blog post will provide contrasts between RAD-140 or Testolone vs Ligandrol LGD-4033 vs MK-2866 or Ostarine, three of the most well-known SARMs in the athletic and bodybuilding industries for years now.
SARMs are compounds that bind selectively to androgen receptor in cells. Essentially, SARMs are performance enhancers and each one works differently, and were designed to have specific effects on the human body once used.
SARMs are definitely not anabolic steroids; they are not even part of the same chemical family. What SARMs do essentially is they provide the body with ‘instructions’ on how to function, and the body’s tissues acquiesce under the influence of SARMs.
Technically speaking, SARMs are a means to conquer various metabolic diseases, including bone density problems and muscle tissue wasting.
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RAD-140 or Testolone is a SARM that was developed in 2010 by Radius Health, Inc.
As one of the ‘youngest’ SARMs, it is touted as one of the more efficient modulators, and it was originally developed as a means to help breast cancer patients.
Animal trials of Testolone showed an increase in both bone and muscle density in the animal subjects.
The unique thing about Testolone (at least in animal trials) is that it helps increase lean muscle mass without triggering a most unsavory side effect, which was also to trigger the increase in mass of the prostate in male rats.
Upon closer investigation, Testolone antagonizes the stimulation of the seminal vesicle in mice. Furthermore, the gains experienced by animal test subjects showed no additional strain on the vital organs, including the liver.
Compared to the more conventional side effects of anabolic steroids that can affect multiple organs at a time, Testolone’s selectivity as a cellular modulator appears to have reduced those risks greatly.
Ligandrol LGD 4033
SARM Ligandrol LGD-4033 is a selective androgen receptor modulator that is capable of evading the vital organs of the body that are often ‘hit’ by growth hormones and anabolic steroids, namely, the brain, heart, liver, and kidneys.
Ligandrol is specifically touted as an effective treatment for older patients who have a more difficult time in building and maintaining lean muscle mass.
Within the context of SARMs like Ligandrol, a clear distinction has to be made between young bodybuilders and older bodybuilders (aged 35 and above) as the physiological function of the body begins to dip at age 35, even with sustained exercise and a good diet.
Ligandrol LGD 4033 has been applied by bodybuilders during the cutting and bulking phases, where the body is supposed to lose fat while building lean muscle mass.
Of particular interest here is the fact that a bodybuilder has to combine Ligandrol with a good macronutrient and micronutrient balance in order to get good results, suggesting that Ligandrol affects not just the uptake and distribution of glucose, but also heightens the dispersal and usage of protein, carbohydrates and other nutrients.
This would also explain how Ligandrol helps older bodybuilders retain their muscle mass even if they are 35 years old or older, by improving the systems involved in using nutrients needed for muscle repair and growth.
MK-2866 or Ostarine is a SARM that is primarily associated with bone density increase, muscle growth, lean muscle retention, and joint health.
Unlike other SARMs, Ostarine appears to provide the entire package in terms of helping bodybuilders achieve better results with their regular training programs.
Ostarine is more holistic in its impacts on the body because it not only trains the body to develop denser and stronger bones, but it also helps the patient keep any muscle gains for the long term. Lean muscle retention is different from muscle growth.
Muscle growth can succumb to lean muscle wastage, and Ostarine stands in the way of this, and reduces its impact on the muscles.
Another important aspect of Ostarine is that it is joint-protective, which means the cushion-like tissues between the bones are protected while the patient is working out.
This extra protection leads not only to better performance, but also to less pain, and fewer chances of injury. A patient can get physically stronger if he has healthier joints, mainly because there would no longer be any hindrances to performing sets and movements.
Poor joint health translates to pain during workouts, and this is certainly something that people would avoid, especially when they are cutting and bulking up.
Ostarine, like other SARMs, does not have the side effects that are traditionally associated with anabolic steroids and growth hormones as it acts selectively on specific cellular receptors and tissues.