This will be our review of S4 Andarine or acetamidoxulutamide is a type of selective androgen receptor modulator (SARM).
But contrary to what many people believe, S4 wasn’t developed primarily to address muscle wasting or any of the usual issues associated with degenerative muscle diseases and cancer.
No, S4 actually began as an experimental project to develop an alternative method of male contraception.
Disclaimer: We are not recommending taking this product, yet simply reviewing the product based on our research. S4 Andarine is sold for research purposes only & is not approved for human use or consumption! Please do your own research before making any decisions related to S4 Andarine.
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S4 as male contraceptive
Initially, S4 showed extreme promise as a male contraceptive as it produced two seemingly paradoxical effects once administered. In the first phase, S4 reduced the active creation of new, viable sperm cells (and so it counteracts spermatogenesis) and second, it increases sexual desire or libido!
From the purview of a medical professional who wishes to help a patient reduce his chances of getting a female pregnant while staying sexually active, S4 is extremely notable for its paradoxical effect.
Another wave of surprises came when researchers performed additional research on mice using Andarine.
Take note that the mice during animal trials were previously castrated (their testicles have been removed). Upon administration of Andarine, the mice began exhibiting something that should’ve have been hampered by the removal of the primary site of the male hormone: muscle growth.
The birth of a SARM
This was the time that researchers realized that the experimental compound they had on their hands wasn’t just a a novel male contraceptive method – it was actually a SARM, an extremely potent one at that.
Additionally, researchers also noted an increase in bone density in the castrated mice, as they were recording increases in muscle density, too. Upon closer inspection at related tissues that often took a hit when androgenic substances were administered to mammals, the researchers found out that S4 was selective in its action, which further raised their convictions that indeed, Andarin was a selective androgen receptor modulator.
Mode of action
How does a SARM work, anyway? SARMs can act in three different ways once administered to the human body.
It can act as an androgen receptor antagonist, which simply means that it binds to androgen receptors and prevent the same from activating and expressing genes in different tissues.
Second, it can also act as an androgen receptor agonist. To be an agonist means the compound will bind, detach and bind once again to the target receptor, until it is completely spent or metabolized by the body.
The third mode of action is modulation. A SARM compound can attach to the androgen receptor and modulate or change how the androgen receptor influences how it influences select tissue types.
The types of tissues affected by the action of the SARM is dictated not by the body’s natural androgen receptors, but by the SARMs themselves, making them a perfect counterbalance to synthetic testosterone, which affects not just bones and muscles, but also the male and female reproductive systems.
To clarify, SARMs aid the body by helping it express specific genes that dictate how certain tissues develop. Genes are like tiny blueprints of the body.
Understanding hormones and receptors
The body has superfamilies of genes, hormones and receptors, all working to create balance and homeostasis in the body.
Low testosterone in the body means hormone replacement therapy might be needed – and SARMs are now a novel means of addressing low DHT or low testosterone levels, once such conditions are diagnosed.
What are the key benefits of S4 or Andarine, once administered in a clinical setting? Past studies on animals have shown great promise as it produces obvious, anabolic effects on select tissues.
S4 is now being investigated further as a potential treatment for the following conditions: muscle degeneration or wastage due to degenerative muscle disease, a parallel treatment for osteoporosis and similar brittle-bone conditions, and finally, end-stage kidney failure, otherwise known as severe renal impairment.
At the outset, experimental compounds such as Andarine can help people with degenerative muscle disease by one, preserving the existing lean muscle mass and two, by helping the body create more muscle tissue.
It’s one thing to build muscle tissue, it’s another thing completely to keep what’s already around. Individuals with muscle disease tend to lose muscle mass even when they’re not doing anything, which makes musculature improvement doubly difficult both in the short term and the long term.
Medical testing and animal studies
After extensive animal testing, S4 was approved for an initial Phase 1 medical trial on humans.
The results echoed what was determined feasible with lower mammal studies. In one human study, subjects expressed an average 3.3 pound increase of lean muscle mass within ninety days of use.
Interestingly enough the consistent muscle gain (though moderate) also came with a ‘side effect’ of losing additional adipose or fat tissue. To patients who need to lose adipose tissue, this is a welcome piece of news indeed.
Researchers have also observed that S4 produced amplified anabolic effects that are even greater than conventional anabolic steroids, while preventing organ collateral damage and unsightly gynecomastia, or the enlargement of breast tissue in males.
Fat tissue loss while building great muscle mass was attributed to higher percentages of fat oxidation during the period that the compound was administered.
Liver toxicity was not recorded in the respondents, which shows that S4/Andarine is largely non-hepatoxic, which is another piece of welcome news as steroids have been known to cause not just liver toxicity but also cysts or tumors that later give way to cirrhosis of the liver.
As for other important ratios in the body, the following data have been reported in Phase 1 human trials: very minimal growth in sexual organs in males (i.e. negligible), low-density lipoproteins and high-density lipoproteins were unaffected (which means S4 is largely safe for the heart), zero percentage risk factor for aromatization and lactation in male breast tissue and finally, S4 does not compete against naturally-occurring testosterone in the body.
This particular issue is important for individuals who may require SARM as an alternative means of addressing low testosterone levels, as some SARMs such as YK-11 have been known to block the action of the male hormone testosterone.
This phenomenon is called saturation and it’s something that has to be avoided as naturally-occurring testosterone is still important for the normal functioning of the body.